Cyclic neutropenia

A rare form of neutropenia characterized by regular 21-day cyclic fluctuations in the number of blood NEUTROPHILS; MONOCYTES; EOSINOPHILS; LYMPHOCYTES; PLATELETS, and RETICULOCYTES. Patients experience periodic symptoms of FEVER, malaise, mucosal ulcers, and, rarely, life-threatening infections. The disease occurs both as a hereditary autosomal dominant disorder and in an acquired form, with identical phenotypic presentations. Mutations in the ELANE gene have been identified for the inherited form. OMIM: 162800

Also Known As:

Cyclic Hematopoesis; Cyclic Leucopenia; Cyclic hematopoiesis; Neutropenia, cyclic; Periodic Neutropenia

Hemic and Lymphatic Diseases: 7
- Hematologic Diseases: 3445
  - Cytopenia: 2659
    - Leukopenia: 5923
      - Agranulocytosis: 4086
        Neutropenia: 16871
        Cyclic neutropenia: 212
  - Leukocyte Disorders: 8
    - Leukopenia: 5923
      - Agranulocytosis: 4086
        Neutropenia: 16871
        Cyclic neutropenia: 212

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Disease

Drug/Important Bio-Agent (IBA)